The science-backed guide to annabinoid hyperemesis syndrome

Cannabinoid hyperemesis syndrome

abdominal pain, cannabis hyperemesis syndrome, drug alcohol depend,

Cannabinoid hyperemesis syndrome

United States pharmacy. HHS17-HHS19. Cannabis is often considered a healthy and safe substance, however cannabis hyperemesis is an underlying cause of chronic cannabis use. Clinicians should highly suspect the CHS of a patient who is experiencing persistent gastrointestinal pain or vomiting and is relieved by drinking hot water. Often antiemetics are inadequate for diagnosing CHS. CHS can only be successfully cured if a drug is abstained from using cannabis, though haloperidol may be investigated.


It is largely a generalized diagnostic for abdominal cramping and vomiting. It needs very detailed histories to further tease out the etiology and direct therapy. Clinical images show abdominal cramping, nausea and vomiting. In 2004 a peculiar syndrome of vomiting related to chronic cannabis usage appeared in the literature accompanied by a curious historical qualification which appeared to relieve symptoms by hot water bathing.

Possible treatment options

Support services are recommended in patients in hyperemesis phase in CS. During treatment, patients should drink water in a small dose when they are able to handle it. Several cases of patients with vomiting may have difficulty retaining oral fluid because of excessive vomiting causing IV fluid deficiency. Since electrolytes are prone to disturbance when you vomit, it is recommended to monitor and replace electrolytes. Cold bathing has become an important learned behavior in the treatment of chronic hiccups. Having a warm bath helps with thermoregulation.

Continuing education activities

Cannabinoid hyperemesis syndrome (CHS) is an illness where patients experience cyclical pain, vomiting after taking marijuana. The disease has a number of characteristics) years of prior smoking or drinking marijuana before illness.) the cyclic pattern of hyperemesis every few weeks to months, at which time a doctor is also using cannabis for treatment. Treatment and recovery of symptoms after discontinuation from marijuana use. Symptoms can be relieved by soaking or taking a hot bath or soaking in a hot bath.


Cannabis hyperemia syndrome is difficult to diagnose, due to many reasons. Some patients might hesitate to provide historical evidence of illicit drugs and/or other substances to a physician, as the name may make it difficult to determine whether a diagnosis can be diagnosed. Another barrier to diagnosing includes the close relationship of CHS with others pathologies such as Cyclic Vomit Syndrome (CSS), formerly known as abdominal migraine, due to such patients often having concomitant migraine-like symptoms.


Current information on CH was obtained through numerous case reports and small case collections. Clinical diagnoses are based on thirteen cases of CH. Cannabinoid hyperemia syndrome: clinical diagnosis of a rare chronic cannabis abuse. The largest case-series in this area confirmed key and important criteria for canniotoxic hypo-emesis syndrome clinical diagnosis. A further expansion of these main criteria is required in order to change previously suggested characteristics suggesting a diagnosis”.

Treatment / Management

CHS has an extremely high risk of being treated by pharmacological drugs such as ondansetron and metoclopramide, as the most prevalent. In recent months cases have been written suggesting various treatment methods based around benzodiazepine and tricyclic anti depressive medications, and even antiepileptic drugs such as levetirace. The literature in Emergency Medical and Toxicology examined opiate antagonists such as dopinamine and serotonin.


CHS is susceptible to many problems. In fact, despite frequent vomiting it’s possible to have electrolyte imbalances. Patients unable to receive treatment for antiemetic disorders may develop low levels of nutritional deficiencies due to the lack of anti-hydration. Other known causes for severe and traumatic vomiting include pneumonia and aspiration and subsequently aspiration pneumonitis, and gastrointestinal damage such as boerhave’s syndrome.


A global overview of legalization of cannabis. The World Health Survey on Drinking and Drugs has been published. Cannabinoid hyperemesis : cyclical hyperemesis resulting from cannabis use. Canabinoids are known for causing hyperemesis when bathed with excessive force. Cyclolic vomiting and compulsed bathing during chronic marijuana use. Cannabinoid hyperemic syndrome: a study of cases. Clinical diagnosis of a rare form of cannabis hyperemesis.

Risk factors, clinical course and diagnosis

Chronic use of cannabis can contribute to CHP. Patients who take cannabis regularly will face a risk of CHS if used for long periods of time.8. Using daily cannabis may be more prone to CHS versus more frequent cannabis usage. There are three phases to CHS, including pre-emetic, hyper-emetic and recovery. The pre-emetic period, which can last from months to years, resembles nausea and vomiting. During pregnancy, cannabis can cause nausea.


Physiologic causes for vomiting are related to multiple organ structures. During noxious stimuli perception occurs in the brain postrema and leads to vagal stimulation. The resultant neuro-endocrine mediated processes result in salivation, closure of the glottis to protect the person’s airway from aspiration, relaxation of the stomach’s sphincters, retroperistalsis of small intestinal contents to the intestine

Patients and methods

Inclusion criteria have been defined from reviews by PubMed on cases in the CH series. Based on these findings, patients were considered if they had long-term marijuana consumption prior to onset of their symptoms. They had recurrent symptoms of nausea; There was no major health problem which may have explained this problem.


Cannabinoid hyperemesis may be considered a potential problem if a patient has been smoking marijuana at a low risk. Symptom identification can help diagnose a CH diagnosis, and it is important that patients be asked what relief they can get from a hot bath. Having stopped cannabis usage is able to improve clinical symptoms. Studies require more follow up, and validations of diagnostic criteria are necessary.


A standardized workout is required for a cardiologist if there is a complication of aging or cardiovascular conditions, or for an atypical presentation of pulmonary vascular diseases. A complete blood count (which in conjunction with a suitable travel history, can be evaluated for infectious etiology) also provides information to determine whether a urinary infection has occurred or if ketones are present.

Deterrence and patient education

The end of a disease can involve removal if there is a precipitating cause and not just managing the symptom. It is important to remove all cannabis exposures from patients to ensure the patient has access to the best quality medical care and the right support from their physician. Cannabis is the worlds third most widely used illicit drug by prevalence for people seeking treatment.

Differential diagnosis

Before starting to diagnose HS it is important for patients to find or eliminate any other important diseases against their own age and risk factors that may need emergency treatment or surgery if required. Certainly when we discuss the symptoms and effects of nausea and vomiting gastrointestinal pathologies can leapt up the front page of our minds.


As cannabis is known to mediate vomiting it seems absurd compared to a drug used as an antiemetic for many conditions including multiple sclerosis, chemotherapy, vomiting, and other conditions. It was discovered that chronic over stimulation of neuroendocannabinoids causes derangement in body internal control of nausea and vomiting.

Pertinent studies and ongoing trials

An article published today examined nearly ninety veterans of Veterans Affairs’ health care facilities and evaluated how the role of physical exercise is an aspect of a self-guided cannabis withdrawal programme.

History and Physical

As potential etiologies are recognized, CHS can now use diagnostic tests to evaluate its effectiveness. Rome IV criteria are the most current and the criteria are listed in detail in Table 1.


In general, prognosis is good if diagnostics are made quickly and patients begin smoking cessation. Symptoms worsen with prolonged cannabinoid use.


persistent nausea, chronic cannabis abuse, drug alcohol

Cannabinoid Hyperemesis Syndrome is believed to be related to both the gastrointestinal and central nervous systems. There are two theories on the process by which CHS develops: the cannabinoid buildup theory as well as the hypothalamic hypothesis.

In relation to the theory of buildup of cannabinoid A study from 2011 suggested it is possible that Cannabinoid Hyperemesis Syndrome occurs because of a dysfunction of the stress-response system in central areas. The theory suggests that long-term smokers who smoke heavily accumulate cannabinoids in their bodies. This can cause dysfunction of CB1 and CB2 receptors in the hypothalamus.

Cyclic vomiting syndrome

Specifically, CHS takes the pattern of cyclical nausea, vomiting, and Abdominal pain in the setting of chronic cannabinoid use. The abdominal pain tends to be mild and diffused. There are three phases of CHS the prodromal phase, the hyperemetic phase, and the recovery phase.

cannabis hyperemesis syndrome

The only definitive treatment of Cannabis Hyperemesis Syndrome is the removal of cannabis exposure, which may ultimately require extensive coordination between the committed patient, an empathic and dedicated primary care physician, and appropriate substance use counseling and resources. Cannabis is the most widely used illicit substance in the United States.

Emergency Department

when another person is accompanying the partner to an appointment or emergency department visit. Identifying the correct diagnosis saves money for the healthcare system and reduces morbidity associated with the condition. Treatment Edit Many traditional medications for nausea and vomiting are ineffective.

Cannabis Hyperemesis Syndrome Characterized

The cannabis hyperemesis syndrome characterized by persistent nausea and vomiting, abdominal pain, and compulsive bathing associated with chronic marijuana use: a report of eight cases in the United States.

A 2015 study of emergency department (ED) presentations in a US state following legalization of medical cannabis found nearly double the rate of cyclic vomiting presentations and higher rates of cannabis use among these patients

Normal Bowel Habits

The next supportive criterion of normal bowel habits is based on the fact that nearly two-thirds of our patients reported this feature; if patients present with a predominance of either diarrhea or constipation, CH may still be present, but additional diagnoses and testing may need to be considered.

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